Sheffield publications in cancer prevention and early diagnosis
The research within this theme describes and analyses the characteristics of Yorkshire populations and patients, and the cancers experienced, to help identify factors that contribute to poor outcomes. The vision is that gaining a better understanding of Yorkshire’s cancer patients, will help to develop targeted interventions and screening programmes to improve survival, primarily through earlier diagnosis.
Publications
Journal articles
- A multimodal explainable ai framework to assist in the differential diagnosis of head and neck reactive follicular hyperplasia and follicular lymphoma: an international multicentre study. Virchows Archiv. View this article in WRRO
- Equity impact and cost-effectiveness of a community health worker breast cancer educational programme in rural South Africa: a modelling study. BMJ Open, 16(4). View this article in WRRO
- Multi-site validation of an AI-based biomarker test for determining ER, PR, and HER2 status from H&E-stained breast cancer slides. ESMO Real World Data and Digital Oncology, 12, 100702-100702.
- Thermal and chemical control of emission and excited-state dynamics in non-(TMS)3P-derived InP quantum dots.. J Chem Phys, 164(14).
- Biallelic variants in the noncoding RNA gene RNU4-2 cause a recessive neurodevelopmental syndrome with distinct white matter changes.. Nat Genet.
- Emulsion templating of PCL:PGS methacrylate blends for soft tissue engineering. Frontiers in Bioengineering and Biotechnology, 14, 1758159.
- Effectiveness of non-pharmacological interventions for fatigue in long term conditions: systematic review and network meta-analysis. BMJ Medicine, 5(1), e001746-e001746.
- A Biocompatible and Flexible medium chain length PHA, P(3HB-co-20mol%3HHx) for Neural Tissue Engineering. Journal of Biotechnology.
- Innovative P(3HB)/carbon-based material composites for bone tissue regeneration: Biocompatibility, thermo-mechanical, and structural insights. Materials Today Advances, 29.
- Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group.. Pharmacoeconomics.
- Removal of small fibroids and polyps in patients with infertility and recurrent miscarriage: The HELP Fertility? RCT.. Health Technol Assess, 1-35.
- Proton-coupled electron transfer from the hydride perspective: resolving metal oxidation and protonation in a hydridocarbonyl complex by 2D-IR spectroelectrochemistry. The Journal of Physical Chemistry Letters, 17(10), 3008-3012. View this article in WRRO
- Effectiveness and acceptability of interventions to improve faecal immunochemical test (FIT) return in both asymptomatic (screening) and symptomatic populations: protocol for a systematic review of qualitative and quantitative evidence. BMJ Open, 16(2). View this article in WRRO
- British Society of Gastroenterology and Association of Coloproctology of Great Britain and Ireland position on tranexamic acid in upper and lower gastrointestinal bleeding. Colorectal Disease, 28(2).
- 3D environment favors persistent changes in cell functions and altered morphology, wrinkling, and biomechanical signature of the nucleus. Cell Reports Physical Science, 7(2), 103116-103116.
- Co-solute Effects Reveal the Nature of Weak Forces Governing GLP-1 Oligomers Stability. Journal of Biological Chemistry, 111223-111223.
- A critical comparison of polypropylene and polyurethane sling materials after implantation in a suburethral sheep model. Biomaterials, 328, 123852-123852.
- EE383 Economic evaluation of second-generation colon capsule endoscopy for investigation of the colon through direct visualization. Value in Health, 28(12, Supplement 1), S180-S181. View this article in WRRO
- Gene-specific growth charts for ASXL3-related disorder. American Journal of Medical Genetics Part A. View this article in WRRO
- CO180 Pillcam COLON 2 for Investigation of the COLON Through Direct Visualization: A Systematic Review. Value in Health, 28(12), S78-S78.
- HTA335 The Use of Real-World Evidence in Health Technology Assessment and the Application of the NICE RWE Framework: A Review of NICE Technology Appraisals. Value in Health, 28(12), S471-S472.
- Frigate: A novel dataset comprising wide field-of-view astronomical FITS images of Low Earth Orbit Scenes for machine learning applications. Scientific Data. View this article in WRRO
- Faecal immunochemical test demonstrates modest decline in performance characteristics but additional prognostic roles: An evaluation in a symptomatic primary care cohort. Colorectal Disease, 27(11).
- SUN-744 Family mapping of previously identified patients with pathogenic or likely pathogenic ALPL variants using predictive genotyping and detailed phenotyping approach: the FAME case-control study. Journal of the Endocrine Society, 9(Supplement_1). View this article in WRRO
- The LMSz method - an automatable scalable approach to constructing gene-specific growth charts in rare disorders. European Journal of Human Genetics. View this article in WRRO
- A mixture of attention experts-embedded flow-based generative model to create synthetic cells in single-cell RNA-Seq datasets. PLOS Computational Biology, 21(10). View this article in WRRO
- Revisiting the genetics of hypophosphatasia. Journal of Inherited Metabolic Disease, 48(6). View this article in WRRO
- Harnessing Artificial Intelligence in Head and Neck Oncology Practice. Otolaryngologic Clinics of North America.
- Surgical Interventions Improve Survival in Patients with Metastatic Uveal Melanoma. Clinical Surgical Oncology, 100102-100102.
- NonSysId: Nonlinear System Identification with Improved Model Term Selection for NARMAX Models. Journal of Open Source Software, 10(114), 8028-8028.
- Developing powerful PPIE partnerships in the design of an inclusive weight management service: a case study from the NewDAWN programme. Research Involvement and Engagement, 11. View this article in WRRO
- Cost-effectiveness of different HPV vaccination strategies for cervical cancer prevention in South Africa. Vaccine, 64, 127770-127770.
- Electrospun Fibers of Polyhydroxyalkanoate/Bacterial Cellulose Blends and Their Role in Nerve Tissue Engineering. Macromolecular Materials and Engineering, 310(9).
- Particle stabilised high internal phase emulsion scaffolds with interconnected porosity facilitate cell migration. Biomedical Materials, 20(6). View this article in WRRO
- An economic analysis of BPaL for multidrug-resistant TB in South Africa and the Philippines. IJTLD OPEN, 2(9), 535-541. View this article in WRRO
- 144P Beyond markers: Functional assays and transcriptomics reveal CSC populations in soft tissue sarcomas. ESMO Open, 10, 105721-105721.
- Quantitative faecal immunochemical tests to guide colorectal cancer pathway referral in primary care. A systematic review, meta-analysis and cost-effectiveness analysis. Health Technology Assessment, 29(46). View this article in WRRO
- Circular dichroism and multiphoton circularly polarized luminescence switching using a bis‐perylene diimide macrocycle. Chemistry – A European Journal. View this article in WRRO
- Direct observation of two-channel photodissociation of carbon monoxide from the hemoglobin subunits. Nature Communications, 16(1). View this article in WRRO
- Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK and ROS1 in oral squamous cell carcinoma. BMC Cancer, 25(1). View this article in WRRO
- Pathogenic XPO1 variants cause a dominant neurodevelopmental disorder. Genetics in Medicine, 27(11), 101555-101555.
- Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours. Scientific Reports, 15. View this article in WRRO
- Research evaluation with ChatGPT: is it age, country, length, or field biased?. Scientometrics, 130(10), 5323-5343. View this article in WRRO
- Assessment of vault particles in cancer cell line‐derived extracellular vesicle preparations. Journal of Extracellular Vesicles, 14(8). View this article in WRRO
- Modeling the impact of multicancer early detection tests: a review of natural history of disease models. Medical Decision Making, 45(8), 1013-1024. View this article in WRRO
- Uveal melanoma UK national guidelines: 2023 update. European Journal of Cancer, 228. View this article in WRRO
- Advancing synthetic bone tissue engineering materials: Nano-scale investigation into transitional Interface in carbon dots/ polymer composites. Journal of Colloid and Interface Science, 700(Part 3). View this article in WRRO
- An assessment of the maturity of cancer survival data used in economic models for the National Institute for Health and Care Excellence’s single technology appraisals. Value in Health. View this article in WRRO
- Awakening the sense of the possible: the Symptoms Clinic as liminal affective technology. Social Science & Medicine, 383. View this article in WRRO
- The routine use of a digital tool for the tumor cell fraction quantification in molecular pathology: an international validation of QuANTUM. Pathologica, 117(3), 269-277. View this article in WRRO
- Identifying the Impacts, Obstacles and Information Barriers for Parents of Children Living With Genetic Neurodevelopmental Disorders: A Qualitative Study. Health expectations : an international journal of public participation in health care and health policy, 28(4).
- Cost and effectiveness of differentiated ART service delivery strategies in Zambia: a modelling analysis using routine data. Journal of the International AIDS Society, 28(7). View this article in WRRO
- Publisher Correction: Analysis of R-loop forming regions identifies RNU2-2 and RNU5B-1 as neurodevelopmental disorder genes. Nature Genetics, 1-1.
- Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project. BMJ Public Health, 3(1). View this article in WRRO
- An international ASXL3 natural history study: deep phenotypic analyses including detailed reports of a milder phenotype, novel associations, and clinical recommendations. American Journal of Medical Genetics Part A. View this article in WRRO
- Exploring the role of artificial intelligence in oral pathology: diagnostic and prognostic implications. Journal of Oral Pathology & Medicine. View this article in WRRO
- Uncertainties of Data-Driven Models: Theory and Application to Condition Monitoring. IEEE Transactions on Instrumentation and Measurement, 74, 1-11.
- Correction to: Book Review: Pathological basis of oral and maxillofacial diseases. British Dental Journal, 238(11), 888-888.
- Experience-based co-design of an active case finding service for colorectal cancer in community pharmacies: findings from a focused ethnography. Research Involvement and Engagement, 11. View this article in WRRO
- Deep learning-based electrical impedance spectroscopy analysis for malignant and potentially malignant oral disorder detection. Scientific Reports, 15. View this article in WRRO
- Biosynthesis, characterisation and biocompatibility of a unique and elastomeric medium chain-length polyhydroxyalkanoates for kidney glomerular tissue engineering. Materials Today Bio, 33, 101932-101932.
- Automated classification of oral potentially malignant disorders and oral squamous cell carcinoma using a convolutional neural network framework: a cross-sectional study. The Lancet Regional Health - Americas, 47, 101138-101138.
- Targeting metastasis in paediatric bone sarcomas. Molecular Cancer, 24. View this article in WRRO
- Analysis of R-loop forming regions identifies RNU2-2 and RNU5B-1 as neurodevelopmental disorder genes. Nature Genetics, 57(6), 1362-1366. View this article in WRRO
- Electrospun fibers of polyhydroxyalkanoate/bacterial cellulose blends and their role in nerve tissue engineering. Macromolecular Materials and Engineering. View this article in WRRO
- Breast cancer screening using clinical breast examination: a cost-effectiveness analysis for South Africa. Value in Health Regional Issues, 49. View this article in WRRO
- Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma. Molecular Oncology. View this article in WRRO
- Augmenting orbital debris identification with Neo4j-enabled graph-based retrieval-augmented generation for multimodal large language models. Sensors, 25(11), 3352-3352. View this article in WRRO
- Use of external data to inform overall survival extrapolation in NICE technology appraisals for oncology drugs. Journal of Medical Economics, 28(1), 803-813.
- Pathological basis of oral and maxillofacial diseases. British Dental Journal, 238(10), 765-765.
- A systematic review and meta-analysis of risk factors and predictors of thyroid cancer in patients with thyroid nodules. British Journal of Surgery, 112(Supplement_9).
- Development and validation of an artificial intelligence-based pipeline for predicting oral epithelial dysplasia malignant transformation. Communications Medicine, 5(1). View this article in WRRO
- Health-related Quality of Life in People with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review. Clinical Kidney Journal.
- Mapping Epidermal Growth Factor Receptor-1 Sorting Domains in Endosomes with a Calibrated Three-Dimensional Expansion Microscopy Toolkit. ACS Nano.
- British Society of Gastroenterology and Association of Coloproctology of Great Britain and Ireland position on tranexamic acid in upper and lower gastrointestinal bleeding. Frontline Gastroenterology.
- Reclassification of variants of uncertain significance in type I collagen genes: a national reference laboratory experience. Journal of Medical Genetics.
- Mutational insights and in silico characterization of NEK family kinases in OSCC patients from the Pakistani population. Frontiers in Bioinformatics, 5.
- Spatially resolved single-cell analysis of transcriptomic changes linked with neuropathic pain in human neuromas. Pain. View this article in WRRO
- How do clinician and parent-reported data differ? An analysis of similarity and difference in the datasets from a cross-syndrome genetics cohort study (GenROC). Journal of Medical Genetics.
- Resolving consecutive excited-state evolution in Fe-amido chromophores by wide-band optical transient absorption spectroscopy. Chemical Science.
- Independent Multicentre Validation of the ‘Six‐Point’ Model for Malignant Transformation Risk in Oral Epithelial Dysplasia. Oral Diseases.
- Are H&E-based computational models transforming molecular pathology diagnostics in cancer?. Academia Oncology, 2(4).
- The PRAMS (Perinatal Redesign for Accessing Mental Health Services) Study: a research protocol. BJGP Open, BJGPO.2025.0206-BJGPO.2025.0206.
- Ten tips on performing economic evaluation in kidney disease. Clinical Kidney Journal.
- Evidence-biased medicine? Applying a health equity lens to Sackett's methodological framework. BJGP.
- Effect of a Peripheral Substituent on the Ultrafast Dynamics and the rate of Intersystem Crossing in charge-transfer states of Platinum(II) acetylides. Physical Chemistry Chemical Physics.
- The role of circulating tumor DNA as a prognostic biomarker in plasma of patients with oral squamous cell carcinoma. Odontology.
- Using inverse probability of censoring weighting to estimate hypothetical estimands in clinical trials: Should we implement stabilisation, and if so how?. Statistical Methods in Medical Research.
- Correction to “Electrospun Fibers of Polyhydroxyalkanoate/Bacterial Cellulose Blends and Their Role in Nerve Tissue Engineering”. Macromolecular Materials and Engineering.
- Development of a community research link worker role to enable culturally tailored research and empower marginalised communities to participate: the IBISES model. Research Involvement and Engagement, 11(1).
- Familial NSD1 Exon 3 Deletion Associated with Phenotypic and Epigenetic Variability. Genes, 16(10), 1190-1190.
- Augmented two-stage estimation for treatment switching in oncology trials: Leveraging external data for improved precision. Statistical Methods in Medical Research.
- Setting a vision for British Society of Gastroenterology guidelines: embracing innovation while preserving methodological excellence and clinical utility. Gut.
- GM Mustard in India: An Ex-ante Impact Assessment. National Academy Science Letters.
- Transmissibility function analysis for the detection and localization of damage with nonlinear features in MDOF structural systems. Structural Health Monitoring.
Book chapters
- Qualitative evidence synthesis In Facey KM, Holtorf A-P & Single ANV (Ed.), Patient Involvement in Health Technology Assessment (pp. 177-194). Springer Nature Switzerland View this article in WRRO
- Extracellular ATP and the bone, ATP (pp. 521-543). Elsevier
- Data-Driven Science and Physically Interpretable Machine Learning for Complex Dynamic Systems, Encyclopedia of Systems and Control Engineering (pp. 535-552). Elsevier
- Introduction to Survival Analysis in HTA, R for Health Technology Assessment (pp. 168-202). Chapman and Hall/CRC
Conference proceedings
- SA90 Systematic Review of Doubly Robust Methods for Population-Adjusted Indirect Comparisons. Value in Health, Vol. 28(12) (pp S663-S664)
- MSR214 Using Directed Acyclic Graphs in Matching-Adjusted Indirect Comparison and Simulated Treatment Comparison: Systematic Review and Methodological Insights. Value in Health, Vol. 28(12) (pp S537-S538)
- USING DIRECTED ACYCLIC GRAPHS IN MATCHING-ADJUSTED INDIRECT COMPARISON AND SIMULATED TREATMENT COMPARISON: SYSTEMATIC REVIEW AND METHODOLOGICAL INSIGHTS. VALUE IN HEALTH, Vol. 28(12)
- ECONOMIC EVALUATION OF SECOND-GENERATION COLON CAPSULE ENDOSCOPY FOR INVESTIGATION OF THE COLON THROUGH DIRECT VISUALIZATION. VALUE IN HEALTH, Vol. 28(12)
- THE USE OF REAL-WORLD EVIDENCE IN HEALTH TECHNOLOGY ASSESSMENT AND THE APPLICATION THE NICE RWE FRAMEWORK: A REVIEW OF NICE TECHNOLOGY APPRAISALS. VALUE IN HEALTH, Vol. 28(12)
- PILLCAM COLON 2 FOR INVESTIGATION OF THE COLON THROUGH DIRECT VISUALIZATION: A SYSTEMATIC REVIEW. VALUE IN HEALTH, Vol. 28(12)
- SYSTEMATIC REVIEW OF DOUBLY ROBUST METHODS FOR POPULATION-ADJUSTED INDIRECT COMPARISONS. VALUE IN HEALTH, Vol. 28(12)
- (ID: 231) ‘Mystery shopper’ blood pressure checks in pharmacies: the patient experience. International Journal of Pharmacy Practice, Vol. 33(Supplement_1) (pp i63-i63)
- Genotype-phenotype correlation and familial inheritance of ASXL3-related disorder. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 33 (pp 751-751)
- Variant spectrum and genotype-phenotype correlations in HNRNPK-related disorder (Au-Kline-Okamoto syndrome). EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 33 (pp 837-837)
- Analysis of R-loop forming regions discovers RNU2-2P and RNU5B-1 as non-coding neurodevelopmental disorder genes. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 33 (pp 46-46)
- Investigating the effect of missense variants in HNRNPU-related neurodevelopmental disorder. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 33 (pp 760-760)
- Experience-based Co-design of an Active Case Finding Service for Colorectal Cancer in Community Pharmacies: Findings From a Focused Ethnography. INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, Vol. 32(SUPPL1) (pp 176-176)
- The diagnostic accuracy of ultrasound and genomic tests for the diagnosis of autosomal-dominant polycystic kidney disease: a systematic mapping review. Clinical Kidney Journal, Vol. 18(7) View this article in WRRO
- Developing an angiogenic periosteum substitute to improve delayed bone healing. TISSUE ENGINEERING PART A, Vol. 31(11-12) (pp E894-E894)
- 7752 The LMSz method: a new automatable method for producing gene specific growth charts for children with genetic neurodevelopmental disorders. British Society of Paediatric Endocrinology and Diabetes (pp A46.1-A46)
- Investigating Tabular Generative Models for Synthetic Data Generation in PDAC Bulk Gene Expression Data. International Conference on Statistics: Theory and Applications, 17 August 2025 - 19 August 2025.
Other
Preprints
- DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture, openRxiv.
- Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells, Cold Spring Harbor Laboratory.
- Reduced penetrance of
COL1A1/2
pathogenic variants linked with osteogenesis imperfecta: analysis of a large population cohort, Cold Spring Harbor Laboratory.
- Mapping EGFR1 sorting domains in endosomes with a calibrated 3D expansion microscopy toolkit, Cold Spring Harbor Laboratory.
- Angiogenic PolyHIPE Scaffolds Decorated with Extracellular Matrix as Periosteum Substitutes, Cold Spring Harbor Laboratory.
- Biallelic variants in the non-coding RNA gene RNU4-2 cause a recessive neurodevelopmental syndrome with distinct white matter changes, Cold Spring Harbor Laboratory.
- Effectiveness of non-pharmacological Interventions For Fatigue in Long term conditions (EIFFEL)-systematic review and network meta-analysis, Cold Spring Harbor Laboratory.
- Global Transportability of Clinical Trial Outcomes to Real-World Lung Cancer Populations A case Study using Lung-MAP S1400I, Cold Spring Harbor Laboratory.